Pentoxifylline modulation hepatotoxicity and apoptosis induced by nitrosamine in rats
نویسندگان
چکیده
منابع مشابه
Antioxidant modulation of nevirapine induced hepatotoxicity in rats
HIV/AIDS related mortality has been dramatically reduced by the advent of antiretroviral therapy (ART). However, ART presents with associated adverse effects. One of such adverse effects is hepatotoxicity observed with nevirapine (NVP) containing ART. Since previous studies showed that NVP hepatotoxicity may be due to oxidative stress via generation of oxidative radicals, this study sought to e...
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Organophosphorus compounds induce oxidative stress leading to generation of free radicals and alterations in antioxidant and scavengers of oxygen free radicals. The present study demonstrates the effect of chronic exposure of phorate in causation of oxidative stress in male Sprague-Dawley rats. Phorate was administered orally at doses 0.05, 0.1 and 1 mg/kg of body weight for 60 days. After the ...
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Small amounts of exogenous lipopolysaccharide (LPS) (10 ng/kg-100 microg/kg) enhance the hepatotoxicity of allyl alcohol in male Sprague-Dawley rats. This augmentation of allyl alcohol hepatotoxicity appears to be linked to Kupffer cell function, but the mechanism of Kupffer cell involvement is unknown. Since Kupffer cells produce tumor necrosis factor-alpha (TNF alpha) upon exposure to LPS, an...
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Introduction: Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer’s disease. Triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. In this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (TEDMT) on H2O2-...
متن کاملThe effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats
Objective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the eff...
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ژورنال
عنوان ژورنال: Biomedical and Biotechnology Research Journal (BBRJ)
سال: 2020
ISSN: 2588-9834
DOI: 10.4103/bbrj.bbrj_54_20